What is the difference between Lexapro and Wellbutrin?
Ava Hall
Published Mar 25, 2026
While both Wellbutrin and Lexapro treat depression, they are not the same type of drug, Wellbutrin works by blocking the reuptake of dopamine and norepinephrine in the neuronal synapse, while Lexapro blocks the reuptake of serotonin. All of these neurotransmitters play a role in mood and affect.